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| LOAEL (% COHb) |
NOAEL (% COHb) |
|
|---|---|---|
|
Cardiovascular effects |
||
|
Healthy adults |
||
|
Decreased O2 uptake, decreased work capacity (maximal exercise) |
5.0 - 5.5% |
< 5.0% |
|
Significant decrease in work capacity |
3.3 - 4.2% |
< 3.0% |
|
Strenuous exercise - maximal O2 consumption |
7 - 20% |
|
|
People with ischaemic heart disease |
||
|
Decreased exercise capacity at onset of angina, increased duration of angina |
2.9 - 4.5% |
2.5% |
|
Neurobehavioural effects |
||
|
Healthy adults |
||
|
Statistically significant vigilance decrements |
5.0 -7.6% |
<5.0% |
|
Statistically significant diminution of visual perception, manual dexterity, ability to learn, performance of complex sensorimotor tasks |
5.0 -17% |
<5.0% |
|
Foetal effects |
||
|
Reduced birth weight (non-smoking mothers) |
2.0 - 7.0% |
<2.0% |
Source: Dennison et al, 2002.